Hybrid studies in medicine and public health

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Abstract

In this paper we present an overview of the two main types of hybrid (combined) studies — nested case-control studies and case-cohort studies. Main research questions that can be addressed using these study designs are presented. The methodological features of nested case-control and case-cohort studies as well as their strengths and limitations are described in detail. Moreover, we present how to interpret the results of these studies and give examples from the international peer-reviewed literature.

About the authors

K. K. Kholmatova

Northern State Medical University

Author for correspondence.
Email: kkholmatova@mail.ru
ORCID iD: 0000-0002-5240-6470

Kamila K. Kholmatova — Cand. of Sci (Med.), MPH, Associate Professor of the Department of Hospital Therapy and Endocrinology, Researcher of the International Research Competence Center

Troitsky Av., 51, 163069 Arkhangelsk

Russian Federation

O. A. Kharkova

Northern State Medical University

Email: harkovaolga@yandex.ru
ORCID iD: 0000-0002-3130-2920

Olga A. Kharkova — PhD, associate professor, Department of Research Methodology, Dean of the Faculty of Clinical Psychology,
Social Work and Adaptive Physical Education

51 Troitskiy Prospekt, Arkhangelsk, 163069

Russian Federation

M. A. Gorbatova

Northern State Medical University

Email: marigora@mail.ru
ORCID iD: 0000-0002-6363-9595

Maria A. Gorbatova — Cand. of Sci. (Med.), Associate Professor, Master of Public Health, Associate Professor of the Department
of Pediatric Dentistry

51 Troitskiy Prospekt, Arkhangelsk, 163069

Russian Federation

A. M. Grjibovski

Northern State Medical University; North-Eastern Federal University

Email: A.Grjibovski@yandex.ru
ORCID iD: 0000-0002-5464-0498

Andrej M. Grjibovski — Doctor of Medicine, Head of the Directorate for Research and Innovations, Director of the Central Scientific Research Laboratory; Professor at the Department of Public Health, Public Health, General Hygiene and Bioethics

42 Kulakovskogo St., Yakutsk; Sakha (Yakutia) Republic, 677007; 51 Troitskiy Prospekt, Arkhangelsk, 163069

Russian Federation

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