Тhe role of the glutamatergic system in the mechanism of development of hyperbaric oxygen seizures

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Abstract

The purpose of the scientific article was to study the neurophysiological mechanisms of the occurrence of convulsive activity when breathing oxygen under high pressure under conditions of hyperbaric oxygen and the role of the glutamatergic system in this process.
Research methods: Wistar rats, males, weighing 200–250 g. in the amount of 20 were used in the work. The animals were placed in a pressure chamber and compressed with medical oxygen up to 5 ATА. Behavioral reactions and signs of convulsive activity were recorded in animals during compression and during subsequent exposure. Two experimental groups were previously injected with a glutamine synthetase inhibitor at various concentrations 6 hours before compression.
The main results showed that irreversible inhibition of glutamine synthetase in the rat brain under the action of increased oxygen pressure led to a significant decrease in the latent period of convulsions.

About the authors

O. S. Alekseeva

Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences

Author for correspondence.
Email: osa72@inbox.ru
ORCID iD: 0000-0001-5688-347X

St. Petersburg 

Russian Federation

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