Required sample size for comparing means in two paired samples

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Abstract

This paper continues our series of articles for beginners on required sample size for the most common basic statistical tests used in biomedical research. The most common statistical test for comparing means in paired samples is Student’s paired t-test. In this paper we present a simple algorithm for calculating required sample size for comparing two means in paired samples. As in our earlier papers we demonstrate how to perform calculations using WinPepi and Stata software. Moreover, we have created a table with calculated minimal sample sizes required for using Student’s t-tests for different scenarios with the confidence level of 95% and statistical power of 80%.

About the authors

A. M. Grjibovski

Northern State Medical University; North-Eastern Federal University

Author for correspondence.
Email: Andrej.Grjibovski@gmail.com
ORCID iD: 0000-0002-5464-0498

Grjibovski Andrej Mechislavovich

Arkhangelsk

Yakutsk

Russian Federation

M. A. Gorbatova

Northern State Medical University

Email: marigora@mail.ru
ORCID iD: 0000-0002-6363-9595

Maria A. Gorbatova

Arkhangelsk

Russian Federation

A. N. Narkevich

Рrofessor V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: narkevichart@gmail.com
ORCID iD: 0000-0002-1489-5058

Artem N. Narkevich

Krasnoyarsk

Russian Federation

K. A. Vinogradov

Рrofessor V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: vinogradov16@yandex.ru
ORCID iD: 0000-0001-6224-5618

Konstantin A. Vinogradov

Krasnoyarsk

Russian Federation

References

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